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KMID : 0605720190250030251
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Journal of the Korean Society of Biological Therapies in Psychiatry
2019 Volume.25 No. 3 p.251 ~ p.256
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Effect of Amyloid Deposition in PET on Hippocampal Metabolism in Amnestic-Mild Cognitive Impairment : Pilot Study
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Kim Gi-Ok
Lee Young-Min
Park Je-Min
Lee Byung-Dae
Moon Eun-Soo
Jeong Hee-Jeong
Kim Soo-Yeon
Lee Kang-Youn
Suh Hwa-Gyu
Kim Hak-Jin
Park Kyoung-June
Mun Chi-Woong
Kim Ji-Hoon
Chung Young-In
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Abstract
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Objectives：Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI.
Methods：Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), 18F-fluorodeoxyglucose-positron emission tomography(18FDG-PET) and 18F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ-aMCI(N= 10). The primary outcome was HM using 18FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ-aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume.
Results：We found that HM was more decreased in Aβ+aMCI than Aβ-aMCI. This result was not changed after controlling hippocampal volume.
Conclusion：Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
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KEYWORD
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Amyloid beta, Hippocampal metabolism, Amnestic mild cognitive impairment
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